The incidence of narcolepsy in Europe: Before, during, and after the influenza A(H1N1)pdm09 pandemic and vaccination campaigns
Identifieur interne : 001754 ( Main/Exploration ); précédent : 001753; suivant : 001755The incidence of narcolepsy in Europe: Before, during, and after the influenza A(H1N1)pdm09 pandemic and vaccination campaigns
Auteurs : Leonoor Wijnans [Pays-Bas] ; Coralie Lecomte [Pays-Bas] ; Corinne De Vries [Royaume-Uni] ; Daniel Weibel [Pays-Bas, Suisse] ; Cormac Sammon [Royaume-Uni] ; Anders Hviid [Danemark] ; Henrik Svanström [Danemark] ; Ditte M Lgaard-Nielsen [Danemark] ; Harald Heijbel [Suède] ; Lisen Arnheim Dahlström [Suède] ; Jonas Hallgren [Suède] ; Par Sparen [Suède] ; Poul Jennum [Danemark] ; Mees Mosseveld [Pays-Bas] ; Martijn Schuemie [Pays-Bas] ; Nicoline Van Der Maas [Pays-Bas] ; Markku Partinen [Finlande] ; Silvana Romio [Pays-Bas] ; Francesco Trotta [Italie] ; Carmela Santuccio [Italie] ; Angelo Menna [Italie] ; Giuseppe Plazzi [Italie] ; Keivan Kaveh Moghadam [Italie] ; Salvatore Ferro [Italie] ; Gertjan Lammers [Pays-Bas] ; Sebastiaan Overeem [Pays-Bas] ; Kari Johansen [Suède] ; Piotr Kramarz [Suède] ; Jan Bonhoeffer [Suisse] ; Miriam C. J. M. Sturkenboom [Pays-Bas]Source :
- Vaccine [ 0264-410X ] ; 2013.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Vaccination, Vaccin.
English descriptors
- KwdEn :
Abstract
Background: In August 2010 reports of a possible association between exposure to AS03 adjuvanted pandemic A(H1N1)pdm09 vaccine and occurrence of narcolepsy in children and adolescents emerged in Sweden and Finland. In response to this signal, the background rates of narcolepsy in Europe were assessed to rapidly provide information for signal verification. Methods: We used a dynamic retrospective cohort study to assess the narcolepsy diagnosis rates during the period 2000-2010 using large linked automated health care databases in six countries: Denmark, Finland, Italy, the Netherlands, Sweden and the United Kingdom. Results: Overall, 2608 narcolepsy cases were identified in almost 280 million person years (PY) of follow up. The pooled incidence rate was 0.93 (95% CI: 0. 90-0.97) per 100,000 PY. There were peaks between 15 and 30 year of age (women > men) and around 60 years of age. In the age group 5-19 years olds rates were increased after the start of pandemic vaccination compared to the period before the start of campaigns, with rate ratios (RR) of 1.9 (95% CI: 1.1-3.1) in Denmark, 6.4 (95% CI: 4.2-9.7) in Finland and 7.5 (95% CI: 5.2-10.7) in Sweden. Cases verification in the Netherlands had a significant effect on the pattern of incidence over time. Conclusions: The results of this incidence study provided useful information for signal verification on a population level. The safety signal of increased narcolepsy diagnoses following the start of the pandemic vaccination campaign as observed in Sweden and Finland could be observed with this approach. An increase in narcolepsy diagnoses was not observed in other countries, where vaccination coverage was low in the affected age group, or did not follow influenza A(H1N1)pdm09 vaccination. Patient level analyses in these countries are being conducted to verify the signal in more detail.
Affiliations:
- Danemark, Finlande, Italie, Pays-Bas, Royaume-Uni, Suisse, Suède
- Hollande-Méridionale, Hovedstaden, Latium, Svealand
- Copenhague, Leyde, Rome, Rotterdam, Stockholm
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Uniklinikka</wicri:noRegion></affiliation></author><author><name sortKey="Romio, Silvana" sort="Romio, Silvana" uniqKey="Romio S" first="Silvana" last="Romio">Silvana Romio</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Erasmus University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Trotta, Francesco" sort="Trotta, Francesco" uniqKey="Trotta F" first="Francesco" last="Trotta">Francesco Trotta</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Italian Medicines Agency</s1><s2>Rome</s2><s3>ITA</s3><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Santuccio, Carmela" sort="Santuccio, Carmela" uniqKey="Santuccio C" first="Carmela" last="Santuccio">Carmela Santuccio</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Italian Medicines Agency</s1><s2>Rome</s2><s3>ITA</s3><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Menna, Angelo" sort="Menna, Angelo" uniqKey="Menna A" first="Angelo" last="Menna">Angelo Menna</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Regional Health Authority</s1><s2>Tuscany</s2><s3>ITA</s3><sZ>21 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Regional Health Authority</wicri:noRegion></affiliation></author><author><name sortKey="Plazzi, Giuseppe" sort="Plazzi, Giuseppe" uniqKey="Plazzi G" first="Giuseppe" last="Plazzi">Giuseppe Plazzi</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurological Sciences, University of Bologna</s1><s2>, Bologna</s2><s3>ITA</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>, Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Kaveh Moghadam, Keivan" sort="Kaveh Moghadam, Keivan" uniqKey="Kaveh Moghadam K" first="Keivan" last="Kaveh Moghadam">Keivan Kaveh Moghadam</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurological Sciences, University of Bologna</s1><s2>, Bologna</s2><s3>ITA</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>, Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Ferro, Salvatore" sort="Ferro, Salvatore" uniqKey="Ferro S" first="Salvatore" last="Ferro">Salvatore Ferro</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Regional Health Authority</s1><s2>Emilia Romagna</s2><s3>ITA</s3><sZ>24 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Regional Health Authority</wicri:noRegion></affiliation></author><author><name sortKey="Lammers, Gertjan" sort="Lammers, Gertjan" uniqKey="Lammers G" first="Gertjan" last="Lammers">Gertjan Lammers</name><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>25 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Overeem, Sebastiaan" sort="Overeem, Sebastiaan" uniqKey="Overeem S" first="Sebastiaan" last="Overeem">Sebastiaan Overeem</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Neurology, Donders Institute for Neuroscience, Radboud University Nijmegen Medical Centre, PO Box 9101</s1><s2>6500 HB Nijmegen</s2><s3>NLD</s3><sZ>26 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>6500 HB Nijmegen</wicri:noRegion></affiliation></author><author><name sortKey="Johansen, Kari" sort="Johansen, Kari" uniqKey="Johansen K" first="Kari" last="Johansen">Kari Johansen</name><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>European Centre for Disease Prevention and Control</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>27 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Kramarz, Piotr" sort="Kramarz, Piotr" uniqKey="Kramarz P" first="Piotr" last="Kramarz">Piotr Kramarz</name><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>European Centre for Disease Prevention and Control</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>27 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Bonhoeffer, Jan" sort="Bonhoeffer, Jan" uniqKey="Bonhoeffer J" first="Jan" last="Bonhoeffer">Jan Bonhoeffer</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Brighton Collaboration Foundation</s1><s2>Basel</s2><s3>CHE</s3><sZ>4 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Brighton Collaboration Foundation</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>University Children's Hospital</s1><s2>Basel</s2><s3>CHE</s3><sZ>29 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>University Children's Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Sturkenboom, Miriam C J M" sort="Sturkenboom, Miriam C J M" uniqKey="Sturkenboom M" first="Miriam C. J. M." last="Sturkenboom">Miriam C. J. M. Sturkenboom</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Erasmus University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">13-0117033</idno><date when="2013">2013</date><idno type="stanalyst">PASCAL 13-0117033 INIST</idno><idno type="RBID">Pascal:13-0117033</idno><idno type="wicri:Area/PascalFrancis/Corpus">000344</idno><idno type="wicri:Area/PascalFrancis/Curation">001A82</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000181</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000181</idno><idno type="wicri:doubleKey">0264-410X:2013:Wijnans L:the:incidence:of</idno><idno type="wicri:Area/Main/Merge">001778</idno><idno type="wicri:Area/Main/Curation">001754</idno><idno type="wicri:Area/Main/Exploration">001754</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The incidence of narcolepsy in Europe: Before, during, and after the influenza A(H1N1)pdm09 pandemic and vaccination campaigns</title><author><name sortKey="Wijnans, Leonoor" sort="Wijnans, Leonoor" uniqKey="Wijnans L" first="Leonoor" last="Wijnans">Leonoor Wijnans</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Erasmus University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Medicines Evaluation Board</s1><s3>NLD</s3><sZ>1 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>Medicines Evaluation Board</wicri:noRegion></affiliation></author><author><name sortKey="Lecomte, Coralie" sort="Lecomte, Coralie" uniqKey="Lecomte C" first="Coralie" last="Lecomte">Coralie Lecomte</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Erasmus University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="De Vries, Corinne" sort="De Vries, Corinne" uniqKey="De Vries C" first="Corinne" last="De Vries">Corinne De Vries</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University of Bath</s1><s2>Bath</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>University of Bath</wicri:noRegion></affiliation></author><author><name sortKey="Weibel, Daniel" sort="Weibel, Daniel" uniqKey="Weibel D" first="Daniel" last="Weibel">Daniel Weibel</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Erasmus University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Brighton Collaboration Foundation</s1><s2>Basel</s2><s3>CHE</s3><sZ>4 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Brighton Collaboration Foundation</wicri:noRegion></affiliation></author><author><name sortKey="Sammon, Cormac" sort="Sammon, Cormac" uniqKey="Sammon C" first="Cormac" last="Sammon">Cormac Sammon</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University of Bath</s1><s2>Bath</s2><s3>GBR</s3><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>University of Bath</wicri:noRegion></affiliation></author><author><name sortKey="Hviid, Anders" sort="Hviid, Anders" uniqKey="Hviid A" first="Anders" last="Hviid">Anders Hviid</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Statens Serum Institut</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Svanstrom, Henrik" sort="Svanstrom, Henrik" uniqKey="Svanstrom H" first="Henrik" last="Svanström">Henrik Svanström</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Statens Serum Institut</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="M Lgaard Nielsen, Ditte" sort="M Lgaard Nielsen, Ditte" uniqKey="M Lgaard Nielsen D" first="Ditte" last="M Lgaard-Nielsen">Ditte M Lgaard-Nielsen</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Statens Serum Institut</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Heijbel, Harald" sort="Heijbel, Harald" uniqKey="Heijbel H" first="Harald" last="Heijbel">Harald Heijbel</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Swedish Institute for Infectious Disease Control</s1><s2>Lund</s2><s3>SWE</s3><sZ>9 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Swedish Institute for Infectious Disease Control</wicri:noRegion></affiliation></author><author><name sortKey="Arnheim Dahlstrom, Lisen" sort="Arnheim Dahlstrom, Lisen" uniqKey="Arnheim Dahlstrom L" first="Lisen" last="Arnheim Dahlström">Lisen Arnheim Dahlström</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>The Karolinska Institute</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Hallgren, Jonas" sort="Hallgren, Jonas" uniqKey="Hallgren J" first="Jonas" last="Hallgren">Jonas Hallgren</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>The Karolinska Institute</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Sparen, Par" sort="Sparen, Par" uniqKey="Sparen P" first="Par" last="Sparen">Par Sparen</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>The Karolinska Institute</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Jennum, Poul" sort="Jennum, Poul" uniqKey="Jennum P" first="Poul" last="Jennum">Poul Jennum</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Danish Center for Sleep Medicine</s1><s2>Copenhagen</s2><s3>DNK</s3><sZ>13 aut.</sZ></inist:fA14><country>Danemark</country><placeName><settlement type="city">Copenhague</settlement><region type="région" nuts="2">Hovedstaden</region></placeName></affiliation></author><author><name sortKey="Mosseveld, Mees" sort="Mosseveld, Mees" uniqKey="Mosseveld M" first="Mees" last="Mosseveld">Mees Mosseveld</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Erasmus University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Schuemie, Martijn" sort="Schuemie, Martijn" uniqKey="Schuemie M" first="Martijn" last="Schuemie">Martijn Schuemie</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Erasmus University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Van Der Maas, Nicoline" sort="Van Der Maas, Nicoline" uniqKey="Van Der Maas N" first="Nicoline" last="Van Der Maas">Nicoline Van Der Maas</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>National Institute of Public Health</s1><s2>Bilthoven</s2><s3>NLD</s3><sZ>16 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>National Institute of Public Health</wicri:noRegion></affiliation></author><author><name sortKey="Partinen, Markku" sort="Partinen, Markku" uniqKey="Partinen M" first="Markku" last="Partinen">Markku Partinen</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Helsingin Uniklinikka</s1><s2>Helsinki</s2><s3>FIN</s3><sZ>17 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>Helsingin Uniklinikka</wicri:noRegion></affiliation></author><author><name sortKey="Romio, Silvana" sort="Romio, Silvana" uniqKey="Romio S" first="Silvana" last="Romio">Silvana Romio</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Erasmus University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Trotta, Francesco" sort="Trotta, Francesco" uniqKey="Trotta F" first="Francesco" last="Trotta">Francesco Trotta</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Italian Medicines Agency</s1><s2>Rome</s2><s3>ITA</s3><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Santuccio, Carmela" sort="Santuccio, Carmela" uniqKey="Santuccio C" first="Carmela" last="Santuccio">Carmela Santuccio</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Italian Medicines Agency</s1><s2>Rome</s2><s3>ITA</s3><sZ>19 aut.</sZ><sZ>20 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Menna, Angelo" sort="Menna, Angelo" uniqKey="Menna A" first="Angelo" last="Menna">Angelo Menna</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Regional Health Authority</s1><s2>Tuscany</s2><s3>ITA</s3><sZ>21 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Regional Health Authority</wicri:noRegion></affiliation></author><author><name sortKey="Plazzi, Giuseppe" sort="Plazzi, Giuseppe" uniqKey="Plazzi G" first="Giuseppe" last="Plazzi">Giuseppe Plazzi</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurological Sciences, University of Bologna</s1><s2>, Bologna</s2><s3>ITA</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>, Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Kaveh Moghadam, Keivan" sort="Kaveh Moghadam, Keivan" uniqKey="Kaveh Moghadam K" first="Keivan" last="Kaveh Moghadam">Keivan Kaveh Moghadam</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Department of Neurological Sciences, University of Bologna</s1><s2>, Bologna</s2><s3>ITA</s3><sZ>22 aut.</sZ><sZ>23 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>, Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Ferro, Salvatore" sort="Ferro, Salvatore" uniqKey="Ferro S" first="Salvatore" last="Ferro">Salvatore Ferro</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Regional Health Authority</s1><s2>Emilia Romagna</s2><s3>ITA</s3><sZ>24 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Regional Health Authority</wicri:noRegion></affiliation></author><author><name sortKey="Lammers, Gertjan" sort="Lammers, Gertjan" uniqKey="Lammers G" first="Gertjan" last="Lammers">Gertjan Lammers</name><affiliation wicri:level="3"><inist:fA14 i1="15"><s1>Leiden University Medical Center</s1><s2>Leiden</s2><s3>NLD</s3><sZ>25 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Overeem, Sebastiaan" sort="Overeem, Sebastiaan" uniqKey="Overeem S" first="Sebastiaan" last="Overeem">Sebastiaan Overeem</name><affiliation wicri:level="1"><inist:fA14 i1="16"><s1>Department of Neurology, Donders Institute for Neuroscience, Radboud University Nijmegen Medical Centre, PO Box 9101</s1><s2>6500 HB Nijmegen</s2><s3>NLD</s3><sZ>26 aut.</sZ></inist:fA14><country>Pays-Bas</country><wicri:noRegion>6500 HB Nijmegen</wicri:noRegion></affiliation></author><author><name sortKey="Johansen, Kari" sort="Johansen, Kari" uniqKey="Johansen K" first="Kari" last="Johansen">Kari Johansen</name><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>European Centre for Disease Prevention and Control</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>27 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Kramarz, Piotr" sort="Kramarz, Piotr" uniqKey="Kramarz P" first="Piotr" last="Kramarz">Piotr Kramarz</name><affiliation wicri:level="3"><inist:fA14 i1="17"><s1>European Centre for Disease Prevention and Control</s1><s2>Stockholm</s2><s3>SWE</s3><sZ>27 aut.</sZ><sZ>28 aut.</sZ></inist:fA14><country>Suède</country><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Bonhoeffer, Jan" sort="Bonhoeffer, Jan" uniqKey="Bonhoeffer J" first="Jan" last="Bonhoeffer">Jan Bonhoeffer</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Brighton Collaboration Foundation</s1><s2>Basel</s2><s3>CHE</s3><sZ>4 aut.</sZ><sZ>29 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Brighton Collaboration Foundation</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="18"><s1>University Children's Hospital</s1><s2>Basel</s2><s3>CHE</s3><sZ>29 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>University Children's Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Sturkenboom, Miriam C J M" sort="Sturkenboom, Miriam C J M" uniqKey="Sturkenboom M" first="Miriam C. J. M." last="Sturkenboom">Miriam C. J. M. Sturkenboom</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Erasmus University Medical Center</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>14 aut.</sZ><sZ>15 aut.</sZ><sZ>18 aut.</sZ><sZ>30 aut.</sZ></inist:fA14><country>Pays-Bas</country><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Vaccine</title><title level="j" type="abbreviated">Vaccine</title><idno type="ISSN">0264-410X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Epidemiology</term><term>Europe</term><term>Immunological adjuvant</term><term>Incidence</term><term>Influenza A</term><term>Influenza A virus</term><term>Narcolepsy</term><term>Vaccination</term><term>Vaccine</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Virus grippal A</term><term>Incidence</term><term>Epidémiologie</term><term>Narcolepsie</term><term>Europe</term><term>Vaccination</term><term>Vaccin</term><term>Adjuvant immunologique</term><term>Grippe A</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccination</term><term>Vaccin</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: In August 2010 reports of a possible association between exposure to AS03 adjuvanted pandemic A(H1N1)pdm09 vaccine and occurrence of narcolepsy in children and adolescents emerged in Sweden and Finland. In response to this signal, the background rates of narcolepsy in Europe were assessed to rapidly provide information for signal verification. Methods: We used a dynamic retrospective cohort study to assess the narcolepsy diagnosis rates during the period 2000-2010 using large linked automated health care databases in six countries: Denmark, Finland, Italy, the Netherlands, Sweden and the United Kingdom. Results: Overall, 2608 narcolepsy cases were identified in almost 280 million person years (PY) of follow up. The pooled incidence rate was 0.93 (95% CI: 0. 90-0.97) per 100,000 PY. There were peaks between 15 and 30 year of age (women > men) and around 60 years of age. In the age group 5-19 years olds rates were increased after the start of pandemic vaccination compared to the period before the start of campaigns, with rate ratios (RR) of 1.9 (95% CI: 1.1-3.1) in Denmark, 6.4 (95% CI: 4.2-9.7) in Finland and 7.5 (95% CI: 5.2-10.7) in Sweden. Cases verification in the Netherlands had a significant effect on the pattern of incidence over time. Conclusions: The results of this incidence study provided useful information for signal verification on a population level. The safety signal of increased narcolepsy diagnoses following the start of the pandemic vaccination campaign as observed in Sweden and Finland could be observed with this approach. An increase in narcolepsy diagnoses was not observed in other countries, where vaccination coverage was low in the affected age group, or did not follow influenza A(H1N1)pdm09 vaccination. Patient level analyses in these countries are being conducted to verify the signal in more detail.</div></front></TEI><affiliations><list><country><li>Danemark</li><li>Finlande</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>Suède</li></country><region><li>Hollande-Méridionale</li><li>Hovedstaden</li><li>Latium</li><li>Svealand</li></region><settlement><li>Copenhague</li><li>Leyde</li><li>Rome</li><li>Rotterdam</li><li>Stockholm</li></settlement></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Wijnans, Leonoor" sort="Wijnans, Leonoor" uniqKey="Wijnans L" first="Leonoor" last="Wijnans">Leonoor Wijnans</name></region><name sortKey="Lammers, Gertjan" sort="Lammers, Gertjan" uniqKey="Lammers G" first="Gertjan" last="Lammers">Gertjan Lammers</name><name sortKey="Lecomte, Coralie" sort="Lecomte, Coralie" uniqKey="Lecomte C" first="Coralie" last="Lecomte">Coralie Lecomte</name><name sortKey="Mosseveld, Mees" sort="Mosseveld, Mees" uniqKey="Mosseveld M" first="Mees" last="Mosseveld">Mees Mosseveld</name><name sortKey="Overeem, Sebastiaan" sort="Overeem, Sebastiaan" uniqKey="Overeem S" first="Sebastiaan" last="Overeem">Sebastiaan Overeem</name><name sortKey="Romio, Silvana" sort="Romio, Silvana" uniqKey="Romio S" first="Silvana" last="Romio">Silvana Romio</name><name sortKey="Schuemie, Martijn" sort="Schuemie, Martijn" uniqKey="Schuemie M" first="Martijn" last="Schuemie">Martijn Schuemie</name><name sortKey="Sturkenboom, Miriam C J M" sort="Sturkenboom, Miriam C J M" uniqKey="Sturkenboom M" first="Miriam C. J. M." last="Sturkenboom">Miriam C. J. M. Sturkenboom</name><name sortKey="Van Der Maas, Nicoline" sort="Van Der Maas, Nicoline" uniqKey="Van Der Maas N" first="Nicoline" last="Van Der Maas">Nicoline Van Der Maas</name><name sortKey="Weibel, Daniel" sort="Weibel, Daniel" uniqKey="Weibel D" first="Daniel" last="Weibel">Daniel Weibel</name><name sortKey="Wijnans, Leonoor" sort="Wijnans, Leonoor" uniqKey="Wijnans L" first="Leonoor" last="Wijnans">Leonoor Wijnans</name></country><country name="Royaume-Uni"><noRegion><name sortKey="De Vries, Corinne" sort="De Vries, Corinne" uniqKey="De Vries C" first="Corinne" last="De Vries">Corinne De Vries</name></noRegion><name sortKey="Sammon, Cormac" sort="Sammon, Cormac" uniqKey="Sammon C" first="Cormac" last="Sammon">Cormac Sammon</name></country><country name="Suisse"><noRegion><name sortKey="Weibel, Daniel" sort="Weibel, Daniel" uniqKey="Weibel D" first="Daniel" last="Weibel">Daniel Weibel</name></noRegion><name sortKey="Bonhoeffer, Jan" sort="Bonhoeffer, Jan" uniqKey="Bonhoeffer J" first="Jan" last="Bonhoeffer">Jan Bonhoeffer</name><name sortKey="Bonhoeffer, Jan" sort="Bonhoeffer, Jan" uniqKey="Bonhoeffer J" first="Jan" last="Bonhoeffer">Jan Bonhoeffer</name></country><country name="Danemark"><region name="Hovedstaden"><name sortKey="Hviid, Anders" sort="Hviid, Anders" uniqKey="Hviid A" first="Anders" last="Hviid">Anders Hviid</name></region><name sortKey="Jennum, Poul" sort="Jennum, Poul" uniqKey="Jennum P" first="Poul" last="Jennum">Poul Jennum</name><name sortKey="M Lgaard Nielsen, Ditte" sort="M Lgaard Nielsen, Ditte" uniqKey="M Lgaard Nielsen D" first="Ditte" last="M Lgaard-Nielsen">Ditte M Lgaard-Nielsen</name><name sortKey="Svanstrom, Henrik" sort="Svanstrom, Henrik" uniqKey="Svanstrom H" first="Henrik" last="Svanström">Henrik Svanström</name></country><country name="Suède"><noRegion><name sortKey="Heijbel, Harald" sort="Heijbel, Harald" uniqKey="Heijbel H" first="Harald" last="Heijbel">Harald Heijbel</name></noRegion><name sortKey="Arnheim Dahlstrom, Lisen" sort="Arnheim Dahlstrom, Lisen" uniqKey="Arnheim Dahlstrom L" first="Lisen" last="Arnheim Dahlström">Lisen Arnheim Dahlström</name><name sortKey="Hallgren, Jonas" sort="Hallgren, Jonas" uniqKey="Hallgren J" first="Jonas" last="Hallgren">Jonas Hallgren</name><name sortKey="Johansen, Kari" sort="Johansen, Kari" uniqKey="Johansen K" first="Kari" last="Johansen">Kari Johansen</name><name sortKey="Kramarz, Piotr" sort="Kramarz, Piotr" uniqKey="Kramarz P" first="Piotr" last="Kramarz">Piotr Kramarz</name><name sortKey="Sparen, Par" sort="Sparen, Par" uniqKey="Sparen P" first="Par" last="Sparen">Par Sparen</name></country><country name="Finlande"><noRegion><name sortKey="Partinen, Markku" sort="Partinen, Markku" uniqKey="Partinen M" first="Markku" last="Partinen">Markku Partinen</name></noRegion></country><country name="Italie"><region name="Latium"><name sortKey="Trotta, Francesco" sort="Trotta, Francesco" uniqKey="Trotta F" first="Francesco" last="Trotta">Francesco Trotta</name></region><name sortKey="Ferro, Salvatore" sort="Ferro, Salvatore" uniqKey="Ferro S" first="Salvatore" last="Ferro">Salvatore Ferro</name><name sortKey="Kaveh Moghadam, Keivan" sort="Kaveh Moghadam, Keivan" uniqKey="Kaveh Moghadam K" first="Keivan" last="Kaveh Moghadam">Keivan Kaveh Moghadam</name><name sortKey="Menna, Angelo" sort="Menna, Angelo" uniqKey="Menna A" first="Angelo" last="Menna">Angelo Menna</name><name sortKey="Plazzi, Giuseppe" sort="Plazzi, Giuseppe" uniqKey="Plazzi G" first="Giuseppe" last="Plazzi">Giuseppe Plazzi</name><name sortKey="Santuccio, Carmela" sort="Santuccio, Carmela" uniqKey="Santuccio C" first="Carmela" last="Santuccio">Carmela Santuccio</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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